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Looking for protein stabilizing drugs with thermal shift assay
Thermal shift assay can be used for the high‐throughput screening of pharmacological chaperones. These drugs are small molecules that bind a mutant protein and stabilize it. We demonstrated the robustness, reproducibility and versatility of the method using two molecules that are in clinical trial f...
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| Pubblicato in: | Drug Test Anal |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6681132/ https://ncbi.nlm.nih.gov/pubmed/25845367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dta.1798 |
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