Cyclization of Single-Chain Fv Antibodies Markedly Suppressed Their Characteristic Aggregation Mediated by Inter-Chain VH-VL Interactions

Single-chain Fv (scFv) antibodies are recombinant proteins in which the variable regions of the heavy chain (VH) and light chain (VL) are connected by a short flexible polypeptide linker. ScFvs have the advantages of easy genetic manipulation and low-cost production using Escherichia coli compared w...

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Vydáno v:Molecules
Hlavní autoři: Yamauchi, Soichiro, Kobashigawa, Yoshihiro, Fukuda, Natsuki, Teramoto, Manaka, Toyota, Yuya, Liu, Chenjiang, Ikeguchi, Yuka, Sato, Takashi, Sato, Yuko, Kimura, Hiroshi, Masuda, Takeshi, Ohtsuki, Sumio, Noi, Kentaro, Ogura, Teru, Morioka, Hiroshi
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681014/
https://ncbi.nlm.nih.gov/pubmed/31323851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24142620
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