A Novel 3-Phytosterone-9α-Hydroxylase Oxygenation Component and Its Application in Bioconversion of 4-Androstene-3,17-Dione to 9α-Hydroxy-4-Androstene-3,17-Dione Coupling with A NADH Regeneration Formate Dehydrogenase

9α-Hydroxy-4-androstene-3,17-dione (9-OH-AD) is one of the significant intermediates for the preparation of β-methasone, dexamethasone, and other steroids. In general, the key enzyme that enables the biotransformation of 4-androstene-3,17-dione (AD) to 9-OH-AD is 3-phytosterone-9α-hydroxylase (KSH),...

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Publicado no:Molecules
Main Authors: Zhang, Xian, Zhu, Manchi, Han, Rumeng, Zhao, Youxi, Chen, Kewei, Qian, Kai, Shao, Minglong, Yang, Taowei, Xu, Meijuan, Xu, Jianzhong, Rao, Zhiming
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680482/
https://ncbi.nlm.nih.gov/pubmed/31336696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24142534
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