TOPK inhibits autophagy by phosphorylating ULK1 and promotes glioma resistance to TMZ

ULK1, the upper-most protein of the ULK1 complex, is emerging as a crucial node in autophagy induction. However, the regulation of ULK1 is not fully understood. In this study, we identified TOPK (T-LAK cell-originated protein kinase), an oncokinase, as a novel upstream kinase to phosphorylate ULK1....

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Lu, Hui, Xiao, Juanjuan, Ke, Changshu, Ni, Xiaofang, Xiu, Ruijuan, Tian, Qin, Pan, Huaxiong, Zou, Ling, Wang, Fei, Ma, Tengfei, Ji, Xinying, Yuan, Ping, Liu, Lin, Zhang, Jianmin, Jia, Wei, Duan, Qiuhong, Zhu, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680050/
https://ncbi.nlm.nih.gov/pubmed/31378785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1805-9
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