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HDAC3 deficiency promotes liver cancer through a defect in H3K9ac/H3K9me3 transition

DNA damage triggers diverse cancers, particularly hepatocellular carcinoma (HCC), but the intrinsic link between DNA damage and tumorigenesis remains unclear. Due to its role as an epigenetic and transcriptional regulator, histone deacetylase 3 (HDAC3) is essential for DNA damage control and is ofte...

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Bibliografski detalji
Izdano u:Cancer Res
Glavni autori: Ji, Hongjie, Zhou, Yongjie, Zhuang, Xiang, Zhu, Yongjie, Wu, Zhenru, Lu, Yanrong, Li, Shengfu, Zeng, Yong, Lu, Qing R., Huo, Yanying, Shi, Yujun, Bu, Hong
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679938/
https://ncbi.nlm.nih.gov/pubmed/31097476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3767
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