Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations

BACKGROUND: The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the cellular level. METHODS: Peripheral blood mononuclear cells from healthy donors were incubated with different JAKis, levels of phospho...

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Dettagli Bibliografici
Pubblicato in:Arthritis Res Ther
Autori principali: McInnes, Iain B., Byers, Nicole L., Higgs, Richard E., Lee, Jonathan, Macias, William L., Na, Songqing, Ortmann, Robert A., Rocha, Guilherme, Rooney, Terence P., Wehrman, Thomas, Zhang, Xin, Zuckerman, Steven H., Taylor, Peter C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679539/
https://ncbi.nlm.nih.gov/pubmed/31375130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-1964-1
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