The effects of crizotinib in a transgenic Drosophila model expressing the human TPM4-ALK fusion gene or TPM4

Anaplastic lymphoma kinase (ALK) fusion events lead to constitutive activation of the ALK kinase domain, thereby functioning as oncogenic drivers. These fusion proteins have been identified in numerous cancers. Crizotinib, a small molecule inhibitor of c-Met and ALK, is a Food and Drug Administratio...

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Detalhes bibliográficos
Publicado no:Biol Open
Main Authors: Kim, Yoo Jin, Cho, A-Ri, Sul, Hee Jung, Kim, Bohyun, Kim, A-Young, Kim, Hyeong Su, Seo, Jong Bok, Koh, Youngho, Zang, Dae Young
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679403/
https://ncbi.nlm.nih.gov/pubmed/31278140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.044362
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