The effects of crizotinib in a transgenic Drosophila model expressing the human TPM4-ALK fusion gene or TPM4

Anaplastic lymphoma kinase (ALK) fusion events lead to constitutive activation of the ALK kinase domain, thereby functioning as oncogenic drivers. These fusion proteins have been identified in numerous cancers. Crizotinib, a small molecule inhibitor of c-Met and ALK, is a Food and Drug Administratio...

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Udgivet i:Biol Open
Main Authors: Kim, Yoo Jin, Cho, A-Ri, Sul, Hee Jung, Kim, Bohyun, Kim, A-Young, Kim, Hyeong Su, Seo, Jong Bok, Koh, Youngho, Zang, Dae Young
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679403/
https://ncbi.nlm.nih.gov/pubmed/31278140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.044362
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