Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus

Status epilepticus may decrease mitochondrial biogenesis, resulting in neuronal cell death occurring in the hippocampus. Sirtuin 1 (SIRT1) functionally interacts with peroxisome proliferator-activated receptors and γ coactivator 1α (PGC-1α), which play a crucial role in the regulation of mitochondri...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Chuang, Yao-Chung, Chen, Shang-Der, Jou, Shuo-Bin, Lin, Tsu-Kung, Chen, Shu-Fang, Chen, Nai-Ching, Hsu, Chung-Yao
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6678762/
https://ncbi.nlm.nih.gov/pubmed/31340436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20143588
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