Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells

Mutated forms of the RAS oncogene drive 30% of all cancers, but they cannot be targeted therapeutically using currently available drugs. The molecular and cellular mechanisms that create a heterogenous tumor environment harboring both mutant and wild-type RAS have not been elucidated. In this study,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancers (Basel)
Prif Awduron: Desir, Snider, Wong, Phillip, Turbyville, Thomas, Chen, De, Shetty, Mihir, Clark, Christopher, Zhai, Edward, Romin, Yevgeniy, Manova-Todorova, Katia, Starr, Timothy K., Nissley, Dwight V., Steer, Clifford J., Subramanian, Subbaya, Lou, Emil
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6678395/
https://ncbi.nlm.nih.gov/pubmed/31247990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11070892
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