Tumor-associated macrophages and individual chemo-susceptibility are influenced by iron chelation in human slice cultures of gastric cancer

Purpose: Presence of tumor-associated macrophages (TAM) and high levels of ferritin and lipocalin 2 (Lcn2) in the tumor microenvironment are associated with poor prognosis in many types of cancer. Here we investigate whether iron deprivation influences TAM phenotype and chemotherapy resistance in tu...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Prill, Sebastian, Rebstock, Jakob, Tennemann, Anja, Körfer, Justus, Sönnichsen, Rasmus, Thieme, René, Gockel, Ines, Lyros, Orestis, Monecke, Astrid, Wittekind, Christian, Weimann, Arved, Grosser, Kerstin, Wiechmann, Volker, Kubick, Christoph, Bechmann, Ingo, Lordick, Florian, Kallendrusch, Sonja
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677664/
https://ncbi.nlm.nih.gov/pubmed/31413815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27089
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