Placenta-specific epimutation at H19-DMR among common pregnancy complications: its frequency and effect on the expression patterns of H19 and IGF2

BACKGROUND: H19 and IGF2 genes are imprinted and involved in regulating fetal and placental growth. The H19 differentially methylated region (DMR) is paternally methylated and maternally unmethylated and regulates the imprinted expression of H19 and IGF2. Epimutation at the H19-DMR in humans results...

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Vydáno v:Clin Epigenetics
Hlavní autoři: Yamaguchi, Yuko, Tayama, Chiharu, Tomikawa, Junko, Akaishi, Rina, Kamura, Hiromi, Matsuoka, Kentaro, Wake, Norio, Minakami, Hisanori, Kato, Kiyoko, Yamada, Takahiro, Nakabayashi, Kazuhiko, Hata, Kenichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676526/
https://ncbi.nlm.nih.gov/pubmed/31370882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0712-3
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