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Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function
BACKGROUND AIMS. Chimeric antigen receptor (CAR) T-cell therapy targeting CD19 has demonstrated remarkable success in targeting B-cell malignancies but is often complicated by serious systemic toxicity in the form of cytokine release syndrome (CRS). CRS symptoms are primarily mediated by interleukin...
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| Publicado no: | Cytotherapy |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6676485/ https://ncbi.nlm.nih.gov/pubmed/28506444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2017.04.001 |
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