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A genome-wide profiling of brain DNA hydroxymethylation in Alzheimer’s disease
INTRODUCTION: DNA methylation is a key epigenetic mechanism in brain aging and Alzheimer’s disease (AD). The newly discovered 5-hydroxymethylcytosine (5hmC) mediates DNA demethylation, is highly abundant in the brain, and is dynamically regulated by life experiences. However, little is known about i...
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| Publié dans: | Alzheimers Dement |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6675576/ https://ncbi.nlm.nih.gov/pubmed/28089213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2016.10.004 |
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