Constitutive STAT5 phosphorylation in CD34(+) cells of patients with primary myelofibrosis: Correlation with driver mutation status and disease severity

Primary Myelofibrosis (PMF) is a myeloproliferative disorder associated with JAK2V617F, Calreticulin (CALR) indels, and MPLW515L/K mutations activating the tyrosine kinase JAK2 and its downstream signaling pathway. The nature of signaling abnormalities in primary cells from PMF patients is poorly un...

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Udgivet i:PLoS One
Main Authors: Abbà, Carlotta, Campanelli, Rita, Catarsi, Paolo, Villani, Laura, Abbonante, Vittorio, Sesta, Melania Antonietta, Barosi, Giovanni, Rosti, Vittorio, Massa, Margherita
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675063/
https://ncbi.nlm.nih.gov/pubmed/31369569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220189
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