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Perturbed Interactions of Mutant Proteolipid Protein/DM20 with Cholesterol and Lipid Rafts in Oligodendroglia: Implications for Dysmyelination in Spastic Paraplegia

Missense mutations in the human PLP1 gene lead to dysmyelinating diseases with a broad range of clinical severity, ranging from severe Pelizaeus–Merzbacher disease (PMD) to milder spastic paraplegia type 2 (SPG-2). The molecular pathology has been generally attributed to endoplasmic reticulum (ER) r...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Krämer-Albers, Eva-Maria, Gehrig-Burger, Katja, Thiele, Christoph, Trotter, Jacqueline, Nave, Klaus-Armin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674790/
https://ncbi.nlm.nih.gov/pubmed/17093095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3581-06.2006
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