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Oxidative Stress and Mitogen-Activated Protein Kinase Phosphorylation Mediate Ammonia-Induced Cell Swelling and Glutamate Uptake Inhibition in Cultured Astrocytes

Hepatic encephalopathy (HE) is a major neurological complication in patients with severe liver failure. Elevated levels of ammonia have been strongly implicated as a factor in HE, and astrocytes appear to be the primary target of its neurotoxicity. Mechanisms mediating key aspects of ammonia-induced...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Jayakumar, A. R., Panickar, K. S., Murthy, Ch. R. K., Norenberg, M. D.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674149/
https://ncbi.nlm.nih.gov/pubmed/16672650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0120-06.2006
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