Phosphorylation of Actin-Depolymerizing Factor/Cofilin by LIM-Kinase Mediates Amyloid β-Induced Degeneration: A Potential Mechanism of Neuronal Dystrophy in Alzheimer's Disease

Deposition of fibrillar amyloid β (fAβ) plays a critical role in Alzheimer's disease (AD). We have shown recently that fAβ-induced dystrophy requires the activation of focal adhesion proteins and the formation of aberrant focal adhesion structures, suggesting the activation of a mechanism of ma...

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Vydáno v:J Neurosci
Hlavní autoři: Heredia, Lorena, Helguera, Pablo, de Olmos, Soledad, Kedikian, Gabriela, Solá Vigo, Francisco, LaFerla, Frank, Staufenbiel, Matthias, de Olmos, José, Busciglio, Jorge, Cáceres, Alfredo, Lorenzo, Alfredo
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674046/
https://ncbi.nlm.nih.gov/pubmed/16775141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5567-05.2006
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