Crystal Structures of the Kainate Receptor GluR5 Ligand Binding Core Dimer with Novel GluR5-Selective Antagonists

Glutamate receptor (GluR) ion channels mediate fast synaptic transmission in the mammalian CNS. Numerous crystallographic studies, the majority on the GluR2-subtype AMPA receptor, have revealed the structural basis for binding of subtype-specific agonists. In contrast, because there are far fewer an...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Mayer, Mark L., Ghosal, Alokesh, Dolman, Nigel P., Jane, David E.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2006
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673968/
https://ncbi.nlm.nih.gov/pubmed/16540562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0123-06.2005
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