A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance

Optimal management of neuropathic pain is a major clinical challenge. We investigated the involvement of c-Jun N-terminal kinase (JNK) in neuropathic pain produced by spinal nerve ligation (SNL) (L5). SNL induced a slow (>3 d) and persistent (>21 d) activation of JNK, in particular JNK1, in GF...

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Publié dans:J Neurosci
Auteurs principaux: Zhuang, Zhi-Ye, Wen, Yeong-Ray, Zhang, De-Ren, Borsello, Tiziana, Bonny, Christophe, Strichartz, Gary R., Decosterd, Isabelle, Ji, Ru-Rong
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2006
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673862/
https://ncbi.nlm.nih.gov/pubmed/16571763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5290-05.2006
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