Serotonin Transporter Phosphorylation by cGMP-Dependent Protein Kinase Is Altered by a Mutation Associated with Obsessive–Compulsive Disorder

Human serotonin transporter (hSERT) activity expressed in HeLa cells was stimulated by agents that release nitric oxide, stimulate soluble guanylyl cyclase, or activate cGMP-dependent protein kinase (PKG). This stimulation was blocked by a PKG inhibitor. A naturally occurring mutation, I425V, associ...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Zhang, Yuan-Wei, Gesmonde, Joan, Ramamoorthy, Sammanda, Rudnick, Gary
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2007
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672823/
https://ncbi.nlm.nih.gov/pubmed/17913921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0034-07.2007
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