Nicotine-Induced Dystonic Arousal Complex in a Mouse Line Harboring a Human Autosomal-Dominant Nocturnal Frontal Lobe Epilepsy Mutation

We generated a mouse line harboring an autosomal-dominant nocturnal frontal lobe epilepsy (ADNFLE) mutation: the α4 nicotinic receptor S248F knock-in strain. In this mouse, modest nicotine doses (1–2 mg/kg) elicit a novel behavior termed the dystonic arousal complex (DAC). The DAC includes stereotyp...

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Publicado no:J Neurosci
Main Authors: Teper, Yaroslav, Whyte, Douglas, Cahir, Elizabeth, Lester, Henry A., Grady, Sharon R., Marks, Michael J., Cohen, Bruce N., Fonck, Carlos, McClure-Begley, Tristan, McIntosh, J. Michael, Labarca, Cesar, Lawrence, Andrew, Chen, Feng, Gantois, Ilse, Davies, Philip J., Petrou, Steven, Murphy, Mark, Waddington, John, Horne, Malcolm K., Berkovic, Samuel F., Drago, John
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672658/
https://ncbi.nlm.nih.gov/pubmed/17881519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3042-07.2007
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