Pyrrolidine Dithiocarbamate Activates Akt and Improves Spatial Learning in APP/PS1 Mice without Affecting β-Amyloid Burden

Pyrrolidine dithiocarbamate (PDTC) is a clinically tolerated inhibitor of nuclear factor-κB (NF-κB), antioxidant and antiinflammatory agent, which provides protection in brain ischemia models. In neonatal hypoxia–ischemia model, PDTC activates Akt and reduces activation of glycogen synthase kinase 3...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Malm, Tarja M., Iivonen, Henna, Goldsteins, Gundars, Keksa-Goldsteine, Velta, Ahtoniemi, Toni, Kanninen, Katja, Salminen, Antero, Auriola, Seppo, Van Groen, Thomas, Tanila, Heikki, Koistinaho, Jari
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672417/
https://ncbi.nlm.nih.gov/pubmed/17409235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0059-07.2007
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