Failure to Regulate: Counterproductive Recruitment of Top-Down Prefrontal-Subcortical Circuitry in Major Depression

Eitemau Tebyg

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• Reduced Right Ventrolateral Prefrontal Cortex Activity While Inhibiting Positive Affect is Associated with Improvement in Hedonic Capacity after 8 Weeks of Antidepressant Treatment in Major Depressive Disorder
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• Microstructural Abnormalities in Subcortical Reward Circuitry of Subjects with Major Depressive Disorder
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