Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation

A defect in microtubule (MT)-based transport contributes to the neuronal toxicity observed in Huntington's disease (HD). Histone deacetylase (HDAC) inhibitors show neuroprotective effects in this devastating neurodegenerative disorder. We report here that HDAC inhibitors, including trichostatin...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Dompierre, Jim P., Godin, Juliette D., Charrin, Bénédicte C., Cordelières, Fabrice P., King, Stephen J., Humbert, Sandrine, Saudou, Frédéric
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2007
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672116/
https://ncbi.nlm.nih.gov/pubmed/17392473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0037-07.2007
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