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Modulation of the Purinergic P2X(7) Receptor Attenuates Lipopolysaccharide-Mediated Microglial Activation and Neuronal Damage in Inflamed Brain

We investigated the involvement and roles of the ionotropic purinergic receptor P2X(7)R in microglia in mediating lipopolysaccharide (LPS)-induced inflammatory responses and neuronal damage in rat striatum. A detailed in vivo study showed that LPS injection into striatum markedly increased the expre...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Choi, Hyun B., Ryu, Jae K., Kim, Seung U., McLarnon, James G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672082/
https://ncbi.nlm.nih.gov/pubmed/17475804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5417-06.2007
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