N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease

Niemann-Pick disease type C1 (NPC1) is a fatal, neurodegenerative, cholesterol storage disorder. With new therapeutics in clinical trials, there is an urgency to improve diagnostics and monitor therapeutic efficacy with biomarkers. In this study, we sought to define the structure of an unknown lipid...

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Gepubliceerd in:J Lipid Res
Hoofdauteurs: Sidhu, Rohini, Mondjinou, Yawo, Qian, Mingxing, Song, Haowei, Kumar, Arun Babu, Hong, Xinying, Hsu, Fong-Fu, Dietzen, Dennis J., Yanjanin, Nicole M., Porter, Forbes D., Berry-Kravis, Elizabeth, Vite, Charles H., Gelb, Michael H., Schaffer, Jean E., Ory, Daniel S., Jiang, Xuntian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Biochemistry and Molecular Biology 2019
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672039/
https://ncbi.nlm.nih.gov/pubmed/31201291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000157
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