N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease

Niemann-Pick disease type C1 (NPC1) is a fatal, neurodegenerative, cholesterol storage disorder. With new therapeutics in clinical trials, there is an urgency to improve diagnostics and monitor therapeutic efficacy with biomarkers. In this study, we sought to define the structure of an unknown lipid...

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Библиографические подробности
Опубликовано в: :J Lipid Res
Главные авторы: Sidhu, Rohini, Mondjinou, Yawo, Qian, Mingxing, Song, Haowei, Kumar, Arun Babu, Hong, Xinying, Hsu, Fong-Fu, Dietzen, Dennis J., Yanjanin, Nicole M., Porter, Forbes D., Berry-Kravis, Elizabeth, Vite, Charles H., Gelb, Michael H., Schaffer, Jean E., Ory, Daniel S., Jiang, Xuntian
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Biochemistry and Molecular Biology 2019
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672039/
https://ncbi.nlm.nih.gov/pubmed/31201291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000157
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