Prospective Validation of an Ex Vivo, Patient-Derived 3D Spheroid Model for Response Predictions in Newly Diagnosed Ovarian Cancer

Although 70–80% of newly diagnosed ovarian cancer patients respond to first-line therapy, almost all relapse and five-year survival remains below 50%. One strategy to increase five-year survival is prolonging time to relapse by improving first-line therapy response. However, no biomarker today can a...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Shuford, Stephen, Wilhelm, Christine, Rayner, Melissa, Elrod, Ashley, Millard, Melissa, Mattingly, Christina, Lotstein, Alina, Smith, Ashley M., Guo, Qi Jin, O’Donnell, Lauren, Elder, Jeffrey, Puls, Larry, Weroha, S. John, Hou, Xiaonan, Zanfagnin, Valentina, Nick, Alpa, Stany, Michael P., Maxwell, G. Larry, Conrads, Thomas, Sood, Anil K., Orr, David, Holmes, Lillia M., Gevaert, Matthew, Crosswell, Howland E., DesRochers, Teresa M.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671958/
https://ncbi.nlm.nih.gov/pubmed/31371750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47578-7
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