CLIC1 Function Is Required for β-Amyloid-Induced Generation of Reactive Oxygen Species by Microglia

The Alzheimer's disease (AD) brain is characterized by plaques containing β-amyloid (Aβ) protein surrounded by astrocytes and reactive microglia. Activation of microglia by Aβ initiates production of reactive oxygen species (ROS) by the plasmalemmal NADPH oxidase; the resultant oxidative stress...

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Publicat a:J Neurosci
Autors principals: Milton, Rosemary H., Abeti, Rosella, Averaimo, Stefania, DeBiasi, Silvia, Vitellaro, Laura, Jiang, Lele, Curmi, Paul M. G., Breit, Samuel N., Duchen, Michael R., Mazzanti, Michele
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671295/
https://ncbi.nlm.nih.gov/pubmed/18987185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2431-08.2008
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