Lrig1 Is an Endogenous Inhibitor of Ret Receptor Tyrosine Kinase Activation, Downstream Signaling, and Biological Responses to GDNF

Glial cell line-derived neurotrophic factor (GDNF)/Ret signaling has potent trophic effects on ventral midbrain dopaminergic, motor, sensory, and sympathetic neurons. The molecular mechanisms that restrict Ret receptor tyrosine kinase activation are not well understood. Here, we show that Lrig1, a t...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Ledda, Fernanda, Bieraugel, Oliver, Fard, Shahrzad Shirazi, Vilar, Marçal, Paratcha, Gustavo
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671136/
https://ncbi.nlm.nih.gov/pubmed/18171921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2196-07.2008
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