Age-Dependent Neurodegeneration Accompanying Memory Loss in Transgenic Mice Defective in Mitochondrial Aldehyde Dehydrogenase 2 Activity

Oxidative stress may underlie age-dependent memory loss and cognitive decline. Toxic aldehydes, including 4-hydroxy-2-nonenal (HNE), an end product of lipid peroxides, are known to accumulate in the brain in neurodegenerative disease. We have previously shown that mitochondrial aldehyde dehydrogenas...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ohsawa, Ikuroh, Nishimaki, Kiyomi, Murakami, Yayoi, Suzuki, Yuko, Ishikawa, Masahiro, Ohta, Shigeo
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670537/
https://ncbi.nlm.nih.gov/pubmed/18550766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4956-07.2008
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