Unregulated Cytosolic Dopamine Causes Neurodegeneration Associated with Oxidative Stress in Mice

The role of dopamine as a vulnerability factor and a toxic agent in Parkinson's disease (PD) is still controversial, yet the presumed dopamine toxicity is partly responsible for the “DOPA-sparing” clinical practice that avoids using l-3,4-dihydroxyphenylalanine (l-DOPA), a dopamine precursor, i...

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Pubblicato in:J Neurosci
Autori principali: Chen, Linan, Ding, Yunmin, Cagniard, Barbara, Van Laar, Amber D., Mortimer, Amanda, Chi, Wanhao, Hastings, Teresa G., Kang, Un Jung, Zhuang, Xiaoxi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670521/
https://ncbi.nlm.nih.gov/pubmed/18184785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3602-07.2008
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