Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival

BACKGROUND: Interleukin(IL)-30/IL-27p28 production by Prostate Cancer (PC) Stem-Like Cells (SLCs) has proven, in murine models, to be critical to tumor onset and progression. In PC patients, IL-30 expression by leukocytes infiltrating PC and draining lymph nodes correlates with advanced disease grad...

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Pubblicato in:J Immunother Cancer
Autori principali: Sorrentino, Carlo, Yin, Zhinan, Ciummo, Stefania, Lanuti, Paola, Lu, Li-Fan, Marchisio, Marco, Bellone, Matteo, Di Carlo, Emma
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670138/
https://ncbi.nlm.nih.gov/pubmed/31366386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0668-z
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