Determining clinically meaningful decline in preclinical Alzheimer disease

OBJECTIVE: To determine the time required for a preclinical Alzheimer disease population to decline in a meaningful way, use estimates of decline to update previous clinical trial design assumptions, and identify factors that modify β-amyloid (Aβ)–related decline. METHODS: In 1,120 cognitively unimp...

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Detalhes bibliográficos
Publicado no:Neurology
Main Authors: Insel, Philip S., Weiner, Michael, Mackin, R. Scott, Mormino, Elizabeth, Lim, Yen Ying, Stomrud, Erik, Palmqvist, Sebastian, Masters, Colin L., Maruff, Paul T., Hansson, Oskar, Mattsson, Niklas
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669933/
https://ncbi.nlm.nih.gov/pubmed/31289148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000007831
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