Proteomic identification of a marker signature for MAPKi resistance in melanoma

MAPK inhibitors (MAPKi) show outstanding clinical response rates in melanoma patients harbouring BRAF mutations, but resistance is common. The ability of melanoma cells to switch from melanocytic to mesenchymal phenotypes appears to be associated with therapeutic resistance. High‐throughput, subcell...

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Udgivet i:EMBO J
Main Authors: Paulitschke, Verena, Eichhoff, Ossia, Gerner, Christopher, Paulitschke, Philipp, Bileck, Andrea, Mohr, Thomas, Cheng, Phil F, Leitner, Alexander, Guenova, Emmanuella, Saulite, Ieva, Freiberger, Sandra N, Irmisch, Anja, Knapp, Bernhard, Zila, Nina, Chatziisaak, Theodora‐Pagona, Stephan, Jürgen, Mangana, Joanna, Kunstfeld, Rainer, Pehamberger, Hubert, Aebersold, Ruedi, Dummer, Reinhard, Levesque, Mitchell P
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669927/
https://ncbi.nlm.nih.gov/pubmed/31267558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695874
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