GSTZ1‐1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone

The IGF1R signaling is important in the malignant progression of cancer. However, overexpression of IGF1R has not been properly assessed in HCC. Here, we revealed that GSTZ1‐1, the enzyme in phenylalanine/tyrosine catabolism, is downregulated in HCC, and its expression was negatively correlated with...

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Udgivet i:EMBO J
Main Authors: Yang, Fan, Li, Jingjing, Deng, Haijun, Wang, Yihao, Lei, Chong, Wang, Qiujie, Xiang, Jin, Liang, Li, Xia, Jie, Pan, Xuanming, Li, Xiaosong, Long, Quanxin, Chang, Lei, Xu, Ping, Huang, Ailong, Wang, Kai, Tang, Ni
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669923/
https://ncbi.nlm.nih.gov/pubmed/31267557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019101964
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