Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin

Nuclear protein aggregation has been linked to genome instability and disease. The main source of aggregation‐prone proteins in cells is defective ribosomal products (DRiPs), which are generated by translating ribosomes in the cytoplasm. Here, we report that DRiPs rapidly diffuse into the nucleus an...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Mediani, Laura, Guillén‐Boixet, Jordina, Vinet, Jonathan, Franzmann, Titus M, Bigi, Ilaria, Mateju, Daniel, Carrà, Arianna D, Morelli, Federica F, Tiago, Tatiana, Poser, Ina, Alberti, Simon, Carra, Serena
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669919/
https://ncbi.nlm.nih.gov/pubmed/31271238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018101341
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados