Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals

BACKGROUND: Folate and vitamin B-12 are essential micronutrients involved in the donation of methyl groups in cellular metabolism. However, associations between intake of these nutrients and genome-wide DNA methylation levels have not been studied comprehensively in humans. OBJECTIVE: The aim of thi...

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Detalhes bibliográficos
Publicado no:Am J Clin Nutr
Main Authors: Mandaviya, Pooja R, Joehanes, Roby, Brody, Jennifer, Castillo-Fernandez, Juan E, Dekkers, Koen F, Do, Anh N, Graff, Mariaelisa, Hänninen, Ismo K, Tanaka, Toshiko, de Jonge, Ester A L, Kiefte-de Jong, Jessica C, Absher, Devin M, Aslibekyan, Stella, de Rijke, Yolanda B, Fornage, Myriam, Hernandez, Dena G, Hurme, Mikko A, Ikram, M Arfan, Jacques, Paul F, Justice, Anne E, Kiel, Douglas P, Lemaitre, Rozenn N, Mendelson, Michael M, Mikkilä, Vera, Moore, Ann Z, Pallister, Tess, Raitakari, Olli T, Schalkwijk, Casper G, Sha, Jin, Slagboom, Eline P E, Smith, Caren E, Stehouwer, Coen D A, Tsai, Pei-Chien, Uitterlinden, André G, van der Kallen, Carla J H, van Heemst, Diana, Arnett, Donna K, Bandinelli, Stefania, Bell, Jordana T, Heijmans, Bastiaan T, Lehtimäki, Terho, Levy, Daniel, North, Kari E, Sotoodehnia, Nona, van Greevenbroek, Marleen M J, van Meurs, Joyce B J, Heil, Sandra G
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669135/
https://ncbi.nlm.nih.gov/pubmed/31165884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ajcn/nqz031
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