Covalent chemistry on nanostructured substrates enables noninvasive quantification of gene rearrangements in circulating tumor cells

Well-preserved mRNA in circulating tumor cells (CTCs) offers an ideal material for conducting molecular profiling of tumors, thereby providing a noninvasive diagnostic solution for guiding treatment intervention and monitoring disease progression. However, it is technically challenging to purify CTC...

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Published in:Sci Adv
Main Authors: Dong, Jiantong, Jan, Yu Jen, Cheng, Ju, Zhang, Ryan Y., Meng, Meng, Smalley, Matthew, Chen, Pin-Jung, Tang, Xinghong, Tseng, Patrick, Bao, Lirong, Huang, Tzu-Yang, Zhou, Dongjing, Liu, Yupin, Chai, Xiaoshu, Zhang, Haibo, Zhou, Anqi, Agopian, Vatche G., Posadas, Edwin M., Shyue, Jing-Jong, Jonas, Steven J., Weiss, Paul S., Li, Mengyuan, Zheng, Guangjuan, Yu, Hsiao-hua, Zhao, Meiping, Tseng, Hsian-Rong, Zhu, Yazhen
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669017/
https://ncbi.nlm.nih.gov/pubmed/31392269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav9186
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