Single-cell Transcriptomics Resolves Intermediate Glial Progenitors and Uncovers a Pivotal Determinant of Cell Fate and Gliomagenesis

The identity and heterogeneity of glial progenitors and their contributions to brain tumor malignancy remain elusive. By applying lineage-targeted single-cell transcriptomics, we uncover an unanticipated diversity of glial progenitor pools with unique molecular identities in developing brain. Our an...

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Vydáno v:Cell Stem Cell
Hlavní autoři: Weng, Qinjie, Wang, Jincheng, Wang, Jiajia, He, Danyang, Cheng, Zuolin, Zhang, Feng, Verma, Ravinder, Xu, Lingli, Dong, Xinran, Liao, Yunfei, He, Xuelian, Potter, Andrew, Zhang, Liguo, Zhao, Chuntao, Xin, Mei, Zhou, Qian, Aronow, Bruce J., Blackshear, Perry J., Rich, Jeremy N., He, Qiaojun, Zhou, Wenhao, Suvà, Mario L., Waclaw, Ronald R., Potter, S. Steven, Yu, Guoqiang, Lu, Q. Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669001/
https://ncbi.nlm.nih.gov/pubmed/30982771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.03.006
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