BMP-2 gene delivery in cell-loaded and cell-free constructs for bone regeneration

To induce osteogenicity in bone graft substitutes, plasmid-based expression of BMP-2 (pBMP-2) has been successfully applied in gene activated matrices based on alginate polymer constructs. Here, we investigated whether cell seeding is necessary for non-viral BMP-2 gene expression in vivo. Furthermor...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Loozen, Loek D., Kruyt, Moyo C., Kragten, Angela H. M., Schoenfeldt, Ted, Croes, Michiel, Oner, Cumhur F., Dhert, Wouter J. A., Alblas, Jacqueline
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668905/
https://ncbi.nlm.nih.gov/pubmed/31365542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220028
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