Membralin deficiency dysregulates astrocytic glutamate homeostasis, leading to ALS-like impairment

Mechanisms underlying motor neuron degeneration in amyotrophic lateral sclerosis (ALS) are yet unclear. Specific deletion of the ER-component membralin in astrocytes manifested postnatal motor defects and lethality in mice, causing the accumulation of extracellular glutamate through reducing the glu...

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Vydáno v:J Clin Invest
Hlavní autoři: Jiang, Lu-Lin, Zhu, Bing, Zhao, Yingjun, Li, Xiaoguang, Liu, Tongfei, Pina-Crespo, Juan, Zhou, Lisa, Xu, Wenxi, Rodriguez, Maria J., Yu, Haiyang, Cleveland, Don W., Ravits, John, Da Cruz, Sandrine, Long, Tao, Zhang, Dongxian, Huang, Timothy Y., Xu, Huaxi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668683/
https://ncbi.nlm.nih.gov/pubmed/31112137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127695
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