IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion

Glycosylation of immune receptors and ligands, such as T cell receptor and coinhibitory molecules, regulates immune signaling activation and immune surveillance. However, how oncogenic signaling initiates glycosylation of coinhibitory molecules to induce immunosuppression remains unclear. Here we sh...

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Vydáno v:J Clin Invest
Hlavní autoři: Chan, Li-Chuan, Li, Chia-Wei, Xia, Weiya, Hsu, Jung-Mao, Lee, Heng-Huan, Cha, Jong-Ho, Wang, Hung-Ling, Yang, Wen-Hao, Yen, Er-Yen, Chang, Wei-Chao, Zha, Zhengyu, Lim, Seung-Oe, Lai, Yun-Ju, Liu, Chunxiao, Liu, Jielin, Dong, Qiongzhu, Yang, Yi, Sun, Linlin, Wei, Yongkun, Nie, Lei, Hsu, Jennifer L., Li, Hui, Ye, Qinghai, Hassan, Manal M., Amin, Hesham M., Kaseb, Ahmed O., Lin, Xin, Wang, Shao-Chun, Hung, Mien-Chie
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668668/
https://ncbi.nlm.nih.gov/pubmed/31305264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126022
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