CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs

Transcription factor fusion genes create oncoproteins that drive oncogenesis and represent challenging therapeutic targets. Understanding the molecular targets by which such fusion oncoproteins promote malignancy offers an approach to develop rational treatment strategies to improve clinical outcome...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Okimoto, Ross A., Wu, Wei, Nanjo, Shigeki, Olivas, Victor, Lin, Yone K., Ponce, Rovingaile Kriska, Oyama, Rieko, Kondo, Tadashi, Bivona, Trever G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
Soggetti:
Concise Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668665/
https://ncbi.nlm.nih.gov/pubmed/31329165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126366
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