Determinants of Zika Virus Host Tropism Uncovered by Deep Mutational Scanning

Arboviruses cycle between, and replicate in, both invertebrate and vertebrate hosts, which for Zika virus (ZIKV) involves Aedes mosquitoes and primates(1). The viral determinants required for replication in such obligate hosts are under strong purifying selection during natural virus evolution, maki...

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Publicado no:Nat Microbiol
Main Authors: Setoh, Yin Xiang, Amarilla, Alberto A., Peng, Nias Y.G., Griffiths, Rebecca E., Carrera, Julio, Freney, Morgan E., Nakayama, Eri, Ogawa, Shinya, Watterson, Daniel, Modhiran, Naphak, Nanyonga, Faith Elizabeth, Torres, Francisco J., Slonchak, Andrii, Periasamy, Parthiban, Prow, Natalie A., Tang, Bing, Harrison, Jessica, Hobson-Peters, Jody, Cuddihy, Thom, Cooper-White, Justin, Hall, Roy A., Young, Paul R., Mackenzie, Jason M, Wolvetang, Ernst, Bloom, Jesse D., Suhrbier, Andreas, Khromykh, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667831/
https://ncbi.nlm.nih.gov/pubmed/30886357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0399-4
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