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Interaction of PIAS1 with PRRS virus nucleocapsid protein mediates NF-κB activation and triggers proinflammatory mediators during viral infection

Porcine reproductive and respiratory syndrome virus (PRRSV) activates NF-κB during infection. We examined the ability of all 22 PRRSV genes for NF-κB regulation and determined the nucleocapsid (N) protein as the NF-κB activator. Protein inhibitor of activated STAT1 (signal transducer and activator o...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Ke, Hanzhong, Lee, Sera, Kim, Jineui, Liu, Hsiao-Ching, Yoo, Dongwan
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667501/
https://ncbi.nlm.nih.gov/pubmed/31363150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47495-9
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