Inhibition of the Akt1-mTORC1 Axis Alters Venous Remodeling to Improve Arteriovenous Fistula Patency

Arteriovenous fistulae (AVF) are the most common access created for hemodialysis, but up to 60% do not sustain dialysis within a year, suggesting a need to improve AVF maturation and patency. In a mouse AVF model, Akt1 regulates fistula wall thickness and diameter. We hypothesized that inhibition of...

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Vydáno v:Sci Rep
Hlavní autoři: Guo, Xiangjiang, Fereydooni, Arash, Isaji, Toshihiko, Gorecka, Jolanta, Liu, Shirley, Hu, Haidi, Ono, Shun, Alozie, Michelle, Lee, Shin Rong, Taniguchi, Ryosuke, Yatsula, Bogdan, Nassiri, Naiem, Zhang, Lan, Dardik, Alan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667481/
https://ncbi.nlm.nih.gov/pubmed/31363142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47542-5
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