Personalized Decision Making in Early Stage Breast Cancer: Applying Clinical Prediction Models for Anthracycline Cardiotoxicity and Breast Cancer Mortality Demonstrates Substantial Heterogeneity of Benefit-Harm Trade-off

BACKGROUND: Anthracycline agents can cause cardiotoxicity. We used multivariable risk prediction models to identify a subset of patients with breast cancer at high risk of cardiotoxicity, for whom the harms of anthracycline chemotherapy may balance or exceed the benefits. PATIENTS AND METHODS: A cli...

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Pubblicato in:Clin Breast Cancer
Autori principali: Upshaw, Jenica N., Ruthazer, Robin, Miller, Kathy D, Parsons, Susan K., Erban, John K., O’Neill, Anne M., Demissei, Biniyam, Sledge, George, Wagner, Lynne, Ky, Bonnie, Kent, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667295/
https://ncbi.nlm.nih.gov/pubmed/31175052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clbc.2019.04.012
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