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At Immature Mossy-Fiber–CA3 Synapses, Correlated Presynaptic and Postsynaptic Activity Persistently Enhances GABA Release and Network Excitability via BDNF and cAMP-Dependent PKA

In the adult rat hippocampus, the axons of granule cells in the dentate gyrus, the mossy fibers (MF), form excitatory glutamatergic synapses with CA3 principal cells. In neonates, MF release into their targets mainly GABA, which at this developmental stage is depolarizing. Here we tested the hypothe...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Sivakumaran, Sudhir, Mohajerani, Majid H., Cherubini, Enrico
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6666235/
https://ncbi.nlm.nih.gov/pubmed/19244539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5019-08.2009
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