Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

In animal models of diet-induced obesity, the activation of an inflammatory response in the hypothalamus produces molecular and functional resistance to the anorexigenic hormones insulin and leptin. The primary events triggered by dietary fats that ultimately lead to hypothalamic cytokine expression...

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Publicado en:J Neurosci
Autores principales: Milanski, Marciane, Degasperi, Giovanna, Coope, Andressa, Morari, Joseane, Denis, Raphael, Cintra, Dennys E., Tsukumo, Daniela M. L., Anhe, Gabriel, Amaral, Maria E., Takahashi, Hilton K., Curi, Rui, Oliveira, Helena C., Carvalheira, José B. C., Bordin, Silvana, Saad, Mário J., Velloso, Lício A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2009
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664935/
https://ncbi.nlm.nih.gov/pubmed/19144836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2760-08.2009
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