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Synthesis of 9-O-arylated berberines via copper-catalyzed C(Ar)–O coupling reactions
Berberine is a widely used antimicrobial agent in clinic. However, a high dosage is often required due to its low lipophilicity and bioavailability. The current study explores the structural modifications of berberines with potentially lipophilic aryl groups to address this problem. A series of 15 9...
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| Publicado no: | Beilstein J Org Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Beilstein-Institut
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6664384/ https://ncbi.nlm.nih.gov/pubmed/31435439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.15.161 |
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